pharmaceutical patents list

OTC pharmaceutical, health and beauty products for pharmacies of all types and sizes. Honoring Saras wish, we have curated a comprehensive list of all the well-known patent marketplaces, where one could buy and sell patents. Sperry Journal of Virology, 2005, vol. The variant replicase gene of the coronavirus of the present invention may be derived from an IBV. FIG. The vaccine of the invention will be administered in a therapeutically effective amount, which refers to an amount of an active ingredient, e.g., an agent according to the invention, sufficient to effect beneficial or desired results when administered to a subject or patient. The site is both buyers and seller friendly with a huge technology listing, and other than generating some revenue from seller side, it is quite a decent consideration. Johnson & "Aseptic addition" may be attained by filtering through 0.22 micron filters, and by maintaining the mixing equipment sterile by well-known aseptic methods. It adopts an / fold comprised of five -helices, one 3. This ratio represents a particularly preferred ratio and has been discovered to be the optimum re-suspension ratio. We take no post transaction commissions or fees, and creating a listing is easy because your patent is already on our site. The most publicized human coronavirus, SARS-CoV which causes severe acute respiratory syndrome (SARS), has a unique pathogenesis because it causes both upper and lower respiratory tract infections and can also cause gastroenteritis. Many such compounds are known, and are listed in the Physician's Desk Reference, Remington's Pharmaceutical Sciences, or the Merck Index. The present invention also relates to a method for producing such a vaccine which comprises the step of infecting cells, for example Vero cells, with a viral particle comprising a replicase protein as defined in connection with the first aspect of the invention. The fraction at 160 C. and a pressure of 2 kp was collected to get 103 g of faint yellow liquid of 1-bromo-3-(2-methoxyphenoxy)-2-propylalcohol having a yield of 79%. IB QX is a virulent field isolate of IBV. Such as tuberculosis, High BP, Typhoid fever,etc. ), U.S. Pat. What about energy inventions ? NICHD Policies for Data & Safety Monitoring, Clinician-Scientist Investigator (CSI) Curriculum, Office of Administrative Management (OAM), Office of Data Science and Sharing (ODSS), Office of Legislation, Public Policy, and Ethics (OLPPE), Office of Science Policy, Reporting, and Program Analysis (OSPRA), Division of Population Health Research (DiPHR), NCMRR Funding Opportunity Announcements (FOAs), Snapshot of Pregnancy & Infant Development Advances, Snapshot of Adult & Family Health Advances, National Advisory Child Health and Human Development (NACHHD) Council, National Advisory Board on Medical Rehabilitation Research (NABMRR), Task Force on Research Specific to Pregnant Women and Lactating Women (PRGLAC), Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub, BPCA Framework to Enable Pediatric Drug Development, National Child & Maternal Health Education Program, To encourage the pharmaceutical industry to perform pediatric studies to improve labeling for patented drug products used in children, by granting an additional 6 months patent exclusivity, For NIH to prioritize therapeutic areas and sponsor clinical trials and other research for off-patent drug products that need further study in children. can be dissolved in this pre-mix using approximately 30% of the water required for the entire batch. AbbVie Products List. The variant replicase gene may encode a protein which comprises the amino acid mutations Pro to Leu at position 85 of SEQ ID NO: 6, Val to Leu at position 393 of SEQ ID NO: 7, Leu to Ile at position 183 of SEQ ID NO: 8 and Val to Ile at position 209 of SEQ ID NO: 9. Ocean Tomo holds a lot of auctions, and every time lots are up for sale, Ocean Tomo advertises in print media, notifying everyone about the same. These commercially available computer programs can calculate % identity between two or more sequences. In conclusion, IB M41-R was safe in commercial eggs, generated protection against clinical signs and to an extent against ciliostasis. Units, HCAH expands presence in geriatric health market in India by acquiring Seniority, US FDA grants 510(k) clearance for Baebies G6PD test on FINDER platform, AstraZeneca India, 4baseCare collaborate to enhance access to genomic testing for cancer patients in India, Spero Therapeutics ends exclusive license pact with GSK for tebipenem HBr, NRG Therapeutics announces 16 million Series A to advance mitochondrial therapeutics for Parkinsons and ALS, MSF calls on J&J, Otsuka, TB Alliance to remove barriers blocking generic production of bedaquiline & delamanid, TNCDA asks TN govt to strictly implement court order for legible prescription writing by doctors, ICMR set to facilitate development of enhanced diagnostic to detect antimicrobial resistance earlier, TN chapter of AIAC urges govt to establish one more Ayurveda medical college in the state, Pharma counterfeits scene in India and global abysmal, risks patient health & revenue loss for genuine manufacturers, SEC asks Emcure, Sandoz to submit more data for further approval of ophthalmic injections, DELIVER phase III trial shows AstraZenecas Farxiga improved symptom burden and health-related quality of life in patients with mildly reduced or preserved ejection fraction, Manipal Hospitals partners with Google Cloud uses Amwell to transform patient experience, Cipla consolidated net surges by 12% to Rs. You missed out on LicenseLake.com. The horizontal axis depicts the experimental sample number (which corresponds to a specific electrolyte balance between pre-mixes 2 and 3), and the vertical axis depicts either the height of the flocculate in millimeters, or the absolute number of strokes to re-suspend the flocculate, depending upon which of the three bars one is reading. 24. 500 nucleotides at the 3 end corresponding to the M41 S gene sequence. Plasticrelated chemicals impact wildlife by entering niche environments and spreading through different species and food chains. H120 is a commercial live attenuated IBV Massachusetts serotype vaccine strain, attenuated by approximately 120 passages in embryonated chicken eggs. Jokes apart, the tech giant is in fact interested in buying your patents. 1901 to WWII. The variant replicase gene may encode a protein which comprises at least one or more amino acid mutations in any combination of nsp-10, nsp-14, nsp-15 and nsp-16. ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION. The cell may express or be induced to express T7 polymerase in order to rescue the recombinant viral particle. Biol., 454:255-73 (2008). A coronavirus expressing a variant replicase according to the present invention may cause wheezing in less than 70%, less than 60%, less than 50%, less than 40%, less than 30%, less than 20% or less than 10% of the number of birds in a flock infected with the a virus expressing the wild type replicase. antibiotics, antiseptics, chemotherapeutics, BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING, MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA, Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof, Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes, Transferases (2.) In particular, the quinolone anti-infective Ciprofloxacin (Bayer Corporation, Pharmaceutical Division, West Haven, Conn.) is demonstrated herein. The method of claim 1 wherein the first sterile pre-mix contains in addition a preservative. For purposes of this invention, an effective amount of drug, compound, or pharmaceutical composition is an amount sufficient to reduce the incidence of Infectious Bronchitis. This is a list of legal terms relating to patents. Virol., 154(3):495-9 (2009). The present inventors chose to use this strain as they had worked for many years on this virus, and because the sequence of the complete virus genome is available. Working down from the top of the pre-mix 3 schematic, Tween 20 (Polysorbate 20) was dissolved in approximately 6.5% water of the batch by weight and added aseptically to the sterilized hydrocortisone-salt mixture by passing it through a 0.22 m filter (total pre-mix weight at this point is approximately 10% of the batch size). The cell may be used to produce the coronavirus particle. Coronaviruses are divided into four groups, as shown below: The variant replicase gene of the coronavirus of the present invention may be derived from an alphacoronavirus such as TGEV; a betacoronavirus such as MHV; or a. Next is sterile-filtering an aqueous solution of a mixture of a pharmaceutically-active compound, which results in a It is the sellers who ought to pay a price, $49.95 precisely. This is because suspensions which tend to settle out over time may form hard "cakes" which do not rediperse upon shaking. Thats the gist I came to after reading through its seller side brokerage page. Source https://www.tynax.com/topicdirectory. Often the practice includes taking out new patents (for example over associated delivery systems or new pharmaceutical mixtures), or by buying out To begin, sellers can submit their patents on the ICAPs website for consideration. 30.5 g (0.252 mol) of 2,6-xylidine, 100 ml of ethyl acetate, 26.5 g (0.25 mol) of sodium carbonate were successively added into a 250 ml of 3-neck flask and placed in an ice-water bath. 13. The variant replicase gene may encode a protein which comprises the amino acid mutation Val to Ile at position 209 of SEQ ID NO: 9. For example, the subject may be a chick, chicken or mouse (such as a laboratory mouse, e.g. 1 is a schematic which is comprised of three separate sub-trees showing three corresponding sub-processes depicted as pre-mix 1, pre-mix 2 and pre-mix 3. Can your organization help to link serious patent buyers for some of these useful remedies for preventable diseases. Mutations can also occur in the S gene which may also affect immunogenicity so that the desired immune response is affected and the potential vaccine may not protect against the required serotype. 17. Biol. Often the practice includes taking out new patents (for example over associated delivery systems or new pharmaceutical mixtures), or by buying out The second sterile pre-mix is made by filtering under sterile conditions a mixture of water, a pharmaceutically active compound, acetic acid, and a partial amount of an electrolyte to give a second sterile pre-mix. Thursday, November 3, 2022 - 12:17pm. Bioinformatics, 23:2947-2948). It may be double or single stranded, it may be DNA or RNA or combinations thereof. Our mission as your distribution partner is to help you improve the quality of care and service you deliver to patients and customers, and drive better financial results for your business. the virus is pathogenic to the embryo). This is in contrast to the current state-of-the-art which is that one salt, sodium chloride, is required in order to keep the hydrocortisone out of solution at the higher temperatures of the wet steam method. Nsp-14 comprises a 3-to-5 exoribonuclease (ExoN) active domain in the amino-terminal region. PROCESS FOR THE PREPARATION OF PHARMACEUTICAL SUSPENSIONS TO BE INHALED. The variant replicase gene encoded by the coronavirus of the present invention comprises a mutation in one or more of the sections of sequence encoding nsp-10, nsp-14, nsp-15 or nsp-16. AVMR) Files More Patents. Sell your patents to big ole Google, so that they can use it to make the world better. These new combinations would be within the spirit and scope of this invention. the commercial aspects of intellectual property, such as patents; public procurement, and; foreign direct investment. November 9, 2022 +1-202-455-5058 sales@greyb.com. The plasmid of the present invention comprises a nucleotide sequence capable of encoding a defined region of the replicase protein. Large stocks of the recombining virus including the modified replicase gene (e.g. Only packaging components, or containers etc. The aseptic filtration technique cannot be utilized for suspension products due to non-filterability of suspended particles, which requires passing the product through a 0.22 m filter, and is suited only for solution products with low to moderate viscosity which can be filtered through such a fine filter. infection) or to reduce or prevent development of at least one symptom associated with the disease. The filtrate was washed with 3N HCl to get 50 ml of liquid having a pH of 1-2 and further treated with 50 ml of saturated sodium carbonate solution to adjust pH to 9-10. SARS-CoV ExoN has been demonstrated to have metal ion-dependent 3-to-5 exoribonuclease activity that acts on both single-stranded and double-stranded RNA, but not on DNA. kinases (2.7), RNA-directed RNA polymerase (2.7.7.48), i.e. The method of claim 1 wherein a pharmaceutically compatible acid, base or buffer in sufficient amount to result in a pH that enables solubilization of said pharmaceutically active compound is optionally included. The tetrahydrofuran was then dropwise added under reflux till turbidity. A 70% reduction in hatchability is seen in some cases. A method for producing a vaccine according to. A summary of the functions of coronavirus nsp proteins is provided in Table 1. EUPOL COPPS (the EU Coordinating Office for Palestinian Police Support), mainly through these two sections, assists the Palestinian Authority in building its institutions, for a future Palestinian state, focused on security and justice sector reforms. Given that this virus was produced by multiple passage in SPF embryonated eggs, similar methodology for classical IBV vaccines, it is likely that this virus is pathogenic for embryos. Cafepharma is a site for the pharmaceutical/medical industry. This article is very informative and helpful. The $68.7 billion Activision Blizzard acquisition is key to Microsofts mobile gaming plans. The total volume was made up aseptically to 97% of the batch size using water and passing it through a 0.22 m filter. The key step in the process, steam sterilization of hydrocortisone-the main suspended particle component, involves a carefully balanced minimum quantity of water and use of an electrolyte in the hydrocortisone slurry to avoid solubilization during heating and subsequent recrystallization of hydrocortisone on cooling. Overall, there is not much variability between the different formulations, demonstrating that they all behave similarly, which is the goal. Before sharing sensitive information, make sure you're on a federal government site. Just like its predecessor, ICAP post holding an auction, publishes about the same in digital media, in form of promotions or advertisements. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Pharmabiz.com - India's most comprehensive online pharma news service. 1901 to WWII. International Preliminary Report on Patentability, International Application No. The pathogenicity of a coronavirus may be assessed utilising methods well-known in the art. China remains the largest exporter of active pharmaceutical ingredients, accounting for 40% of the world market per an A patent is not a right to practice or use the invention, but a territorial right to exclude others from commercially exploiting the invention, granted to an inventor or his successor in rights in exchange to a FIG. The variant replicase gene may encode a protein which comprises the amino acid mutation Pro to Leu at position 85 of SEQ ID NO: 6. A particular aspect of the invention has been utilized to produce the Ciprofloxacin-Hydrocortisone otic suspension product. The product was slowly crystallized with cooling and filtrated to get 3.73 g of white solid having a yield of 87.4% by vacuum drying at 40 C. 3.64 g (0.014 mol) of 1-bromo-3-(2-methoxyphenoxy)-2-propylalcohol, 3.1 g (0.012 mol) of N-(2,6-dimethylphenyl)-1-piperazinylacetamide, 4.3 g (0.04 mol) of sodium carbonate, 25 ml of methanol and 50 ml of toluene were successively added into a reaction flask and heated under reflux for 4 h till completion. Buffers include, without limitation, salts prepared from an organic acid or base. The respiratory infection predisposes chickens to secondary bacterial infections which can be fatal in chicks. The coronavirus may be used to produce a vaccine. I do have a green patent and want to sell it what can I do and where can I go to. Our pharmaceutical distribution services. Amino acids in the same block in the second column and preferably in the same line in the third column may be substituted for each other: The coronavirus of the present invention may comprise a variant replicase gene which encodes a protein which comprises a mutation compared to any one of SEQ ID NO: 6, 7, 8 or 9 which, when expressed in a coronavirus, causes the virus to have reduced pathogenicity compared to a coronavirus expressing the corresponding wild-type replicase. Morbidity is 100% in non-vaccinated flocks. 9 is Dexamethasone; FIG. There was no substantial caking over time. 3 is a histogram showing three parameters: the amount of flocculate height after 24 hours (mm), and the number of strokes to re-disperse the flocculate uniformly after 24 hours (note: the terms "re-suspend" and "re-disperse" are used interchangeably throughout). 5 crore in Q2, ERIS Lifesceinces consolidated revenue up by 29% inQ2, inerim dividend of Rs. FIG. The product was extracted three times with 25 ml of dichloromethane each and the lower organic phase was combined. Its common stock is a component of the Dow Jones Industrial Average and the company is ranked No. In addition there are problems associated with reversion to virulence and stability of vaccines. This huge sector improves the quality of life for many people while creating attractive opportunities for long-term investors. challenge in SPF chickens, for design see Table 7. It may also comprise one or more additional coronavirus nucleotide sequence(s), or nucleotide sequence(s) capable of encoding one or more other coronavirus proteins such as the S gene and/or gene 3. The method of administration of the vaccine may be selected from the group consisting of; eye drop administration, intranasal administration, drinking water administration, post-hatch injection and in ovo injection. In 1901 Monsanto was founded in St. Louis, Missouri, as a chemical company. It has a role as a nutraceutical, a radiation protective agent, an anti-ulcer drug, a micronutrient and a fundamental metabolite. It may be isolated, or as part of a plasmid, virus or host cell. Pharmabiz.com - India's most comprehensive online pharma news service. The tetrahydrofuran was then dropwise added under reflux till turbidity. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); on its website, highlighting the exemplary patents in the portfolio. The variant replicase gene may encode a protein which comprises the amino acid mutations Pro to Leu at position 85 of SEQ ID NO: 6, Val to Leu at position 393 of SEQ ID NO: 7 and Val to Ile at position 209 of SEQ ID NO: 9. This may be due to the 10. In this aspect the gold nanoparticles of the invention are modified to be bound to a Positron Succinic acid is an alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It has a role as a nutraceutical, a radiation protective agent, an anti-ulcer drug, a micronutrient and a fundamental metabolite. Western observers have said that China lacks administrative protection for patents. Methods, 123(2):203-11 (2005). Post a successful sale, IP Offerings are paid by the sellers, a pre-decided percentage share in the revenue generated. A therapeutically effective amount of a composition according to the invention may be readily determined by one of ordinary skill in the art. The method of claim 1 wherein said electrolyte is sodium chloride or sodium acetate. In a third aspect, the present invention provides a protein encoded by a variant coronavirus replicase gene according to the second aspect of the invention. Jokes apart, the tech giant is in fact interested in buying your patents. The method of claim 12 wherein said balancing requires minimizing the amount of water in said third sterile pre-mix. It is important that new and safer vaccines are developed for the control of IBV. The mechanism of action of ranolazine is to inhibit partial fatty acid oxidation, which changes fatty acid oxidation to glucose oxidation in heart, and thereby reduces the cardiac oxygen consumption. It first started its patent purchase program in May of 2015 for a three-week window. Further, other water-insoluble pharaceutically active compounds may also be used. Any water-insoluble pharmaceutically active compound that may be formulated as a suspension comes within the scope of this invention. Committed to being free for universities, Not-for-profit research organizations, and other educational institutions for a lifetime, PCTXS does not guarantee to offer its service for free in the future for other entities. Avian infectious bronchitis virus (IBV), the aetiological agent of infectious bronchitis (IB), is a highly infectious and contagious pathogen of domestic fowl that replicates primarily in the respiratory tract but also in epithelial cells of the gut, kidney and oviduct. M41 is a prototypic Massachusetts serotype that was isolated in the USA in 1941. The variant replicase gene may encode a protein which comprises the amino acid mutation Leu to Ile at position 183 of SEQ ID NO: 8. No. In order to develop long-term immunity against the virus, the embryo and hatched chicken must develop an appropriate protective immune response which is distinct to the effect of the maternally-derived antibodies. Pharmaceutical policy is a branch of health policy that deals with the development, provision and use of medications within a health care system. EUPOL COPPS (the EU Coordinating Office for Palestinian Police Support), mainly through these two sections, assists the Palestinian Authority in building its institutions, for a future Palestinian state, focused on security and justice sector reforms. A method for treating and/or preventing a disease in a subject which comprises the step of administering a vaccine according to, 24. The mixture was extracted with dichloromethane and the organic layer was concentrated under vacuum at 60 C. to get 39.4 g of N-(2,6-dimethylphenyl)-1-piperazinylacetamide having a yield of 63%. Owner name: Search by Cooperative Patent Classifications (CPCs): These are commonly used to represent ideas in place of keywords, (2007) Clustal W and Clustal X version 2.0. Pro to Leu at position 85 of SEQ ID NO: 6. IP holders could provide information about the IP in hand, along with valuation expectations and technology details in the seller information form, and within two business days, you could expect communication from an RPX representative. (e) combining all three pre-mixes in sterile fashion thereby achieving a sterile suspended pharmaceutical formulation. The Patents Act 1970, along with the Patents Rules 1972, came into force on 20th April 1972, replacing the Indian Patents and Designs Act 1911. The tetrahydrofuran was then dropwise added under reflux till turbidity. 18. For example a bacterial host cell may be transfected with a plasmid capable of encoding a particular protein, in order to express that protein. Ask Becker and Malackowski of Ocean Tomo, who created the first live public auction of patents, trademarks, and copyright. The focus is mainly to sell the patents to potential buyers in a swift manner. Dear Mr. ZHI ZENG, an amino acid mutation of Val to Ile at the position corresponding to position 209 of SEQ ID NO: 9. compared to the sequence shown as SEQ ID NO: 1; and optionally, comprises one or more nucleotide substitutions selected from T to A at nucleotide position 19047; and, 12. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings, Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g.

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